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CBD and Insomnia

Sleep DisordersSleep disorders refer to abnormal sleep duration or undesirable sleep behavior. This serious medical problem affects our daily functioning, often preventing us from performing the normal activities of life. Today, we feel the need to stay active and awake for long periods of time, and we also have increased exposure to stressors. The availability of artificial lighting means that we often don’t go to bed until dark and don’t have to get up at dawn. In addition, less physical activity associated with a sedentary lifestyle, an irregular lifestyle, or too much bright light in the late afternoon has the effect of deregulating the sleep-wake rhythm. Insomnia is a consequence of this.Do the seasons affect the quality of sleep?There are many factors relevant to our sleep comfort that we can control. A perfectly planned bedroom, good lighting, a comfortable bed or the right temperature is something we can guarantee ourselves. However, not everything that affects healthy sleep depends on us. Seasonal influences such as temperature, cloudiness, wind, air pressure, precipitation or sunlight have a great impact on our well-being.Especially in autumn, it is more difficult for us to ensure the quality of our sleep. The days are getting shorter, so we have much less access to sunlight. Such limited exposure to sunlight can lead to a deficiency of vitamin D3, which is important for maintaining normal serotonin levels in the blood. Serotonin and melatonin are responsible for regulating sleep, so vitamin D deficiency is associated with a disturbed sleep rhythm.Insomnia can also be the result or symptom of other mental disorders. One of these is depression, which we discussed in a previous article. Others are anxiety disorders or alcohol abuse.What effect does the use of CBD have on insomnia?In recent years, CBD oil has been increasingly used as an effective and, above all, safe remedy for insomnia, as it has relatively few risks compared to many other insomnia treatments. It is non-addictive and has a virtually negligible risk of overdose, unlike sleeping pills.When absorbed into the body, CBD oil helps balance our endocannabinoid system that regulates various processes in our body, including the sleep cycle. When applied before bed, it has a calming and soothing effect that facilitates falling asleep.When using CBD oil for insomnia, it is important to choose the right one for your individual needs. When suffering from anxiety or stress, we should use the right CBD applications to have the best possible effect. Different methods of CBD application will produce the right results. For a strong and lasting anxiolytic and analgesic effect, we suggest a sublingual application. Immediate effects will be obtained with an inhaler, but will not be as long-lasting as with other absorption methods.Different concentrations of the oil will soon be available in our store. We will publish more information regularly

https://www.poradnikzdrowie.pl/zdrowie/psychiatria/zaburzenia-snu-rodzaje-przyczyny-leczenie-aa-ZC5D-G54b-2qKu.html

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What is HHC-O?

What is HHC-O?

HHC-O is a new Hemp-derived cannabinoid that is extracted from Hemp using a clean manufacturing process. HHC-O is a hydrogenated compound that binds to different receptors than regular Hemp cannabinoids such as Delta-8. A perk of hydrogenation is that it gives stability at the molecular level. HHC-O is thought to digest in the body the same way as Delta 9 THC. It is said that HHC-O is more potent than Delta-8 and Delta-10. Lastly, HHC-O also has properties that allow it be easier and more efficiently absorbed by the body.

What are the effects of HHC-O?

HHC-O is one of the newest cannabinoids to date as a result there are no definite studies of the long-term effects of HHC-O. However, while using HHC-O, consumers have experience the following: Relaxed, Strong Buzz, Strong Head Buzz and a Strong Body Buzz.

What is the difference between HHC & HHC-o?

Potency

Mostly HHC-O is an upgrade from HHC, and applying acetic anhydride to the compound increases the potency of the cannabinoid by a factor of about 1.5 times, similar to how THC-O is made from THC.

The potency of the product is an important factor you need to consider when deciding between HHC or HHC-O. Based on your experience and tolerance with similar products and the results you want, you need to understand the difference in potency between the two. Alternatively one can start with a low concentration HHC-O product.

Effects

HHC-O is a very new cannabinoid and not enough research has been done to study its effects on the organism. When the popularity begins in 2021, the statistics of users show that the effect of HHC-O is similar to that of HHC, just lasts longer and is more intense, and it is relatively more relaxing than THC. Some users say that HHC-O is easier to control than THC when it starts to kicking-in.

Side Effects

According to different users and different situations, the side effects HHC-O are similar to HHC and THC, mainly the following symptoms:

Anxiety, Dizziness, Dry mouth, Increased appetite, Insomnia, Paranoia, Rapid heart rate, Red eyes.

Safety

Like HHC, HHC-O is a relatively new cannabinoid. There are no studies on the safety of cannabinoids, but there are no reports of anyone suffering any harmful effects from consuming HHC-O products.

Therefore, we cannot say whether there are any safety concerns with this compound. According to user reports, it may have potential recreational and medical benefits. However, dosage must be controlled to avoid unpleasant side effects.

Does HHC-O show up on a drug test?

Some of HHC’s appeal stems from evidence that it can evade drug testing. This is so appealing to some users that HHC fails to detect it on the 12-group drug test.

Because other THC substitutes, such as delta 8 and delta 10 THC, will show up in urine or blood tests for THC if ingested in sufficient amounts.

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Consumption Method On HHC

In this case, we’re referring to your HHC delivery method, or in other words, how you’ll be consuming HHC. Typically, you can either consume HHC by inhaling it, ingesting it in the form of edibles, or by taking it sublingually with oils.

This is where bioavailability comes in. Each method of consumption has its own bioavailability level. This level refers to how much of the compound gets absorbed by the body. Bioavailability essentially affects how much of the HHC you will feel and how long it takes for the effects to kick in.

In general, oral ingestion has the lowest bioavailability level. This is because HHC must first pass through the digestive system before reaching your bloodstream. This process may take some time before you start feeling the effects of HHC.

So if you take an HHC gummy and don’t notice any effects right away, make sure to give it some time before you reach for another one. You don’t want to overdo it and have it hit you all at once.

Meanwhile, inhalation has the highest bioavailability level and is the easiest way to control your HHC intake.

The most popular inhalation method for taking HHC is through vaping. HHC vapes allow for high levels of HHC to enter your bloodstream, so you will feel the effects almost instantly. Start by taking one or two puffs from your HHC vape, wait a bit to feel the effects (you won’t be waiting for long), and then take a few more as you see fit.

By being aware of bioavailability, you can adjust your HHC dosage depending on the chosen consumption method.

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HHC Dosage Guide And Tolerance Level

Dosage guide

How much HHC should you take? How should you consume HHC?

If you’ve had any of those questions, this HHC dosage guide is for you.

The appropriate dose of any psychoactive substance is dependent on various factors, such as age, weight, and tolerance levels.

People turn to cannabinoids to experience the many benefits that they provide. But if you consume too much, you might feel too intoxicated and have a negative experience. Consume too little, and you may not feel the effects – missing out on what this cannabinoid has to offer. Always start on the low end until you know what you’re getting into and how your body will respond.

If you’re a relatively experienced user of one or the other, taking a similar or slightly lower dose of HHC would be a good starting point.

Tolerance level

Your tolerance to cannabinoids is another factor you should consider when you decide how much HHC to take. If you’re a new cannabinoid user, you’ll likely have a low HHC tolerance. This low tolerance means that you will be able to feel the effects of HHC more intensely, even with small doses. So, it’s best to start with small amounts of HHC and then adapt accordingly.

If you have more experience with intoxicating cannabinoids, you’re more likely to tolerate higher doses of HHC. This high tolerance means you’ll need to take more HHC before you achieve your desired effects. Nevertheless, if you haven’t tried HHC before, we suggest starting small and seeing how this specific cannabinoid makes you feel.

Being aware of your tolerance level of intoxicating cannabinoids and HHC can serve as a good frame of reference so you can adjust your dose accordingly.

Another factor that can influence your tolerance level is your body weight. Heavier people tend to have a higher tolerance, so they may need to take more than others to achieve the same effect. Lighter people are likely to have low tolerance, meaning that even a smaller dose could still have big effects on them.

Everybody processes cannabinoids differently. The dose your friend takes may not be right for you.

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Cannabis HHC,THC,CBD,CBG|Compared|

What is HHC ?

HHC was first created in 1944 by the American chemist Roger Adams, when he added hydrogen molecules to Delta-9 THC. This process, known as hydrogenation, converts THC to hexahydrocannabinol (HHC).

What is THC ?

THC, or tetrahydrocannabinol, is the chemical responsible for most of marijuana’s psychological effects. It acts much like the cannabinoid chemicals made naturally by the body.

Cannabinoid receptors are concentrated in certain areas of the brain associated with thinking, memory, pleasure, coordination and time perception.

What is CBD ?

CBD is a chemical found in marijuana. CBD doesn’t contain tetrahydrocannabinol (THC), the psychoactive ingredient found in marijuana that produces a high. The usual CBD formulation is oil, but CBD is also sold as an extract, a vaporized liquid and an oil-based capsule. Food, drinks and beauty products are among the many CBD-infused products available online.

What is CBG ?

(CBG) is a type of cannabinoid obtained from the cannabis plant. It’s often referred to as the mother of all cannabinoids. This is because other cannabinoids are derived from cannabigerolic acid (CBGA), an acidic form of CBG.

What are the differences ?

There is a lack of consensus around HHC’s potency. The complication arises, in part, from the fact that when the cannabinoid is manufactured, the end result is a mixture of two different kinds of HHC molecules:  9R HHC actively binds to the body’s natural endocannabinoid receptors, while 9S HHC, because of its slightly different molecular structure, doesn’t do so nearly as well.

“The one that fits [into the receptors] produces similar effects” as delta-8 THC, but takes a much higher amount to do so, said Richard Sams of KCA Laboratories. “With a sufficient dose, THC-like effects can be observed.”

In other words, HHC can have THC-like effects on the body and mind, but HHC is less potent

While CBD is a prescription cannabidiol (CBD) oil is considered an effective anti-seizure medication. However, further research is needed to determine CBD’s other benefits and safety.

CBD doesn’t contain tetrahydrocannabinol (THC), the psychoactive ingredient found in marijuana that produces a high.

CBG is found in smaller quantities than other cannabinoids in cannabis plants. In most strains of the plant, only 1% of CBG can be found compared to 20 to 25% of CBD or 25 to 30% of THC.

CBG works by binding CB1 and CB2 body receptors where it’s thought to strengthen the function of anandamide, a neurotransmitter that plays a role in enhancing pleasure and motivation, regulating appetite and sleep, and alleviating pain. Unlike THC, CBG has no psychotropic effects, so it will not give you a high.

what is hhc

What Is HHC And How It Works?

What is HHC?

While HHC has been rising in popularity recently, it’s far from a new cannabinoid. HHC (hexahydrocannabinol) was first discovered in 1944 by chemist Roger Adams. Back then, Adams created HHC by adding hydrogen molecules to Delta-9 THC, using a process known as hydrogenation.

Hexahydrocannabinol (HHC) is a naturally occurring phytocannabinoid found in the cannabis plant and is considered a minor cannabinoid. HHC is a hydrogenated derivative of both delta-8 and delta-9 tetrahydrocannabinol (THC). Although it is naturally found in Cannabis sativa in small amounts, it can be produced synthetically by hydrogenation (the addition of molecular hydrogen to a double bond) of cannabis extracts. HHC can also be made from cannabidiol (CBD).

HHC is currently available in a range of products like vape cartridges and HHC gummies. People who buy HHC products enjoy the effects, and many are switching from THC products to HHC products instead.

How it works?

HHC’s chemical structure is nearly identical to THC, so it binds to the same CB1 and CB2 receptors in the endocannabinoid system.

The endocannabinoid system is a modulating system that’s present in all mammals. It helps to regulate vital functions, including sleep, memory, pain, immune system, hunger, mood, and much more.

When you smoke HHC or ingest it, the compound enters the bloodstream and makes its way to your brain. There, it binds with CB1 receptors that tell specific neurons to fire.

This alters things like mood, perception, and appetite—in other words, it gets you high.

Cannabinoids can affect individuals differently, which is why some people are more susceptible to adverse effects. Still, they can help many others reach wellness goals like improving relaxation, sleep quality, and reducing pain.

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CBD and alzheimer’s disease

Światowa Organizacja Zdrowia przedstawia chorobę Alzheimera jako najczęstszą postać demencji, przyczyniającą się do 60-70% jej przypadków. Na całym świecie choroba ta dotyka blisko 50 milionów osób, a każdego roku odnotowuje się około 10 milionów nowych przypadków. 

Co to jest choroba Alzheimera? 

Choroba ta zaliczana jest do chorób neurodegeneracyjnych prowadzących do otępienia. Cierpią na nią głównie osoby po 65 roku życia, dlatego też jej objawy często powiązane są z obniżoną sprawnością umysłową mającą związek z wiekiem. Alzheimer został określony jako przedstarczy zanik mózgu. 

Mimo że, objawy mogą się różnić oraz stopniowo pogarszać, efekt często jest taki sam. Obejmują one upośledzenie funkcji poznawczych, trudności z mówieniem, zanik pamięci zarówno krótkotrwałej  jak i długotrwałej, a także agresywne zachowania, psychozę czy depresję. 

W późniejszych etapach choroby często występuje potrzeba całkowitej opieki specjalistycznej oraz pomoc rodziny osobie dotkniętej tym schorzeniem. 

Tradycyjne leki pomagają w złagodzeniu większości objawów, aczkolwiek leczenie to nie może zatrzymać choroby i odwrócić stanu, do którego ona doprowadziła.  W przypadku CBD najlepszym i najwygodniejszym wyborem będzie olej CBD. Stosowanie należy jednak skonsultować z lekarzem, który ustali odpowiednie stężenie i dawkowanie. 

Jak CBD może pomóc w chorobie Alzheimera? 

Za główną przyczynę demencji uznaje się uszkodzenie połączeń neuronowych w mózgu. Na ich drodze dochodzi do zakłóceń, co wpływa na ich komunikację. CBD stymuluje prawidłową pracę w synapsach połączeń neuronowych poprzez podczepienie się pod receptory CB1. 

Badania kliniczne dowodzą, iż CBD może poprawić problemy behawioralne powodowane przez Alzheimera takie jak problemy z apetytem czy pogarszająca się higiena snu. Wynika to bezpośrednio z roli endokannabinoidów w łagodzeniu procesu neurodegeneracyjnego, który może zapewnić skuteczniejsze sposoby leczenia tego zaburzenia. 

W 2016 roku przeprowadzono nieduże, aczkolwiek znaczące badanie ukazujące wykorzystanie CBD w leczeniu Alzheimera. Grupę 10 pacjentów poddano pomiarowi wpływu CBD na organizm w trakcie 4 tygodniowego okresu badawczego. Badanie wykazało ogromne zmniejszenie wyniku wskaźnika NPI z 44,3 do 12,9, co oznacza wysoki spadek agresji, pobudzenia, apatii czy drażliwości. Sukces tych wyników doprowadził do przeprowadzenia kolejnych badań klinicznych, tym razem już na większa skalę. 

Dawkowanie

Nie ma jednoznacznej odpowiedzi, na to jak dawkować olej CBD. Każdy z nas bowiem ma własne zapotrzebowanie i chłonność systemu endokannabinoidowego. Zależne jest to również od wagi, wieku i stopnia zaawansowania choroby. Tak jak wspomnieliśmy wcześniej najlepiej jest skonsultować dawkę oraz stężenie z lekarzem. 

W naszym sklepie internetowym znajdziecie różne stężenia oraz wersje smakowe suplementów diety NANO CBD. 

Źródła

WHO, „Dementia” [Online] https://www.who.int/news-room/fact-sheets/detail/dementia.

Kluger, Benzi, et al. “The therapeutic potential of cannabinoids for movement disorders.” Movement disorders 30.3 (2015): 313-327

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Does CBD help with depression?

Autumn chandra

According to the international classification of diseases, there is no such thing as fall depression. Still, with shorter days, insufficient sunlight, or bad weather, many people experience depressive disorders. They are manifested by a bad mood, sleep disturbances, appetite disturbances, problems with concentration or decreased self-esteem. For this reason, we decided to briefly explain how and if CBD works for depression at all. Depression is one of the most common mental disorders. It significantly reduces the quality of life, increasing the risk of developing other diseases. According to the World Health Organization, by 2020 it will be the second most common cause of disability in the world and the most common cause of death. While there are many effective treatments for and help people with depression, they often go unrecognized and untreated.

The serotonin system

Serotonin, commonly known as the happiness hormone, is associated with the regulation of mood, while depression with disorders of the serotonin metabolism, but this substance has a much more complex effect. It also affects the functioning of many other neurotransmitters and, which may be surprising – the digestive system – 90% of serotonin is produced in the intestines. As a result, it regulates various body functions and behaviors. In chemical parlance, serotonin is a 5-hydroxyl derivative of trypamine, or 5-HT for short. It binds to serotonin receptors, of which as many as seven different types have been identified, within which there are further subtypes. Drugs and substances that affect our body through the serotonin system are either agonists of serotonin receptors – i.e. they stimulate them, or antagonists – i.e. inhibit their action.

Serotonin and CBD

Cannabidiol binds to serotonin receptors by affecting several different receptors, showing different actions. In addition, it shows little resemblance to the receptors of the endocannabinoid system – that is, the system directly related to it. It modifies the serotonin 5-HT1A receptor, the dysfunction of which can cause depression and the formation of drug states. CBD partially stimulates the receptor, thereby increasing the production of serotonin and dopamine. Research has shown that CBD reduces stress and the resulting anxiety after a single dose. In addition, it improves the quality of sleep, which is necessary for the proper functioning of the brain, which in turn affects the mood.

Tests

Clinical trials by the Maine Research Institute have confirmed the depression-relieving and mood-stabilizing effects of CBD oil by activating paralimbic and limbic areas in the patient’s brain. In turn, laboratory studies conducted at the University of Chicago in 2012 confirmed that medical marijuana, as well as CBD, are effective agents in treating depression. It has also been argued that CBD oil improves cognitive performance in patients suffering from bipolar disorder.

Sources

Wilde, C., RIA neuroscience study points to possible use of medical marijuana for depression (2015) Linge, R., Jiménez-Sánchez, L., Campa, L., Pilar-Cuéllar, F., Vidal, R., Pazos, A., … Díaz, Á. (2016). Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: role of 5-HT1A receptors. Neuropharmacology, 103, 16–26
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CBD and its effects on rheumatoid arthritis (RA)

What is rheumatoid arthritis?

Rheumatoid arthritis or RA for short is an inflammatory disease of a chronic nature that affects the joints and organs. During its occurrence, progressive distortions and stiffening can be observed. Untreated RA can cause joint damage and disability, but also organ damage and death. It is an inflammatory disease that gradually damages cartilage, bones, ligaments and tendons. It is accompanied by pain and swelling. The causes of the disease are not clear, but the most common are the genetic burden and a defect in the immune system.

The factors influencing the development of the disease are:

  • genetics – the risk of developing RA is much higher if the disease occurs earlier in the family;
  • immune system dysfunction – causing bad tissue recognition as “enemy” and producing autoantibodies to destroy them;
  • stress – in some cases, severe stress affects the formation of RA,
  • addiction to cigarettes – people addicted to tobacco are at increased risk,
  • gender – women are much more likely to suffer from RA, infection – some viruses or bacteria can cause the disease.  

How to treat RA?

The basis in the fight against RA are immunosuppressive drugs, i.e. drugs that weaken the reactivity of the immune system. The treatment is also supplemented with non-steroidal anti-inflammatory drugs and glucocorticoids. Recently, biological drugs have also been used, targeting individual pro-inflammatory cytokines, generally administered together with a disease-modifying drug for a year or two or longer, depending on the indications. Numerous studies also confirm the beneficial effects of CBD in treating this disease, which, unlike conventional immunosuppressants, can reduce autoimmunity without affecting the response to infections or cancer.

How does CBD affect RA symptoms?

The positive effect of cannabidiol on RA symptoms begins in the brain. This substance acts on the body thanks to two receptors – CB1, which is most concentrated in the brain, and CB2, which is most concentrated in the joints. Relief of the symptoms of rheumatoid arthritis is caused by CB2 by eliminating some of the abnormal activities of the immune system. Activating the CB1 receptor reduces pain sensitivity in degenerative joints. How to apply CBD for this disease? For rheumatoid arthritis, topical and internal CBD administration is recommended. When it comes to local pain, it is worth using creams or ointments, but the consumption of oils or capsules will also be helpful.

Sources:

http://www.medonet.pl

http://www.poradnikzdrowie.pl

http://www.medycznamarihuana.pl

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CBD use and headaches and migraines

The analgesic effects of CBD are often mentioned in the context of the therapeutic effects of cannabinoids. Headaches and migraines are the most common sources of pain in humans. Therefore, the use of CBD is considered a good alternative to pain medications containing ibuprofen among others. These ailments are usually attributed to dysfunctional brainstem centers, but are considered an unresolved medical mystery. Using CBD may seem like a better way to relieve pain than taking medications that contain the already mentioned ibuprofen. Also, paracetamol, and traps that constrict blood vessels and block pain pathways in the brain.

Migraines and the endocannabinoid system

One theory of the potential causes of migraine is the possible dysregulation of the endocannabinoid system. It is a complex network of receptors and chemicals that work to modulate pain, the immune system, sleep, appetite, memory and mood.

Scientists have been able to observe several mechanisms of the endocannabinoid system that may influence migraine attacks. Anandamide – one of the main endocannabinoids in the body – relieves pain and strengthens serotonin 5-HT1A receptors. These studies also suggest that endocannabinoids inhibit the trigeminovascular system. In 2007, a study was also conducted at the University of Perugia. During it, scientists measured the levels of endocannabinoids in the cerebrospinal fluid of patients with chronic migraines. Finding much smaller amounts of anandamide, they found that “this may reflect a decline in the endocannabinoid system in these patients, which may be contributing to chronic headache.”

Are migraines a sign of clinical CBD deficiency?

Clinical endocannabinoid deficiency is a term coined by neurologist and cannabinoid researcher Dr. Ethan Russo. It arose in response to the association between lower endocannabinoid levels in patients with migraine. Russo relied on the premise that many brain disorders were related to a lack of certain neurotransmitters, including acetylcholine. The neurologist suggested that “comparable failure in endocannabinoid levels may manifest similarly in certain disorders that exhibit predictable clinical features as a consequence of this inconvenience.”

In an interview with the media, however, he described: “If you don’t have enough endocannabinoids, you feel pain where there shouldn’t be pain. You’ll be sick and nauseous. You’ll have a lowered seizure threshold. And a litany of other problems.”

According to Russo, this deficiency can be made up by introducing plant cannabinoids that act similarly to those found in our body and stimulate endocannabinoid receptors. CB1 agonists such as Marinol and Nabilone have been tested for migraine. Russo suggests that the endocannabinoid system requires a “gentle nudge” rather than the “hard push” given by these synthetic variants. Low doses of hemp extract are suggested. One of the variants of taking CBD is the simplest and most effective method, i.e. the sublingual method. It is enough to place a few drops of CBD oil under your tongue.

Sources

https://www.projectcbd.org/dr-ethan-russo-cbd-entourage-effect-and-microbiome